Prion

Definition

A prion is a misfolded protein that induces folding problems in normal variants of the same protein, leading to cellular death. Prions are responsible for prion diseases, which are fatal and transmissible neurodegenerative diseases affecting animals, including humans. These proteins can misfold sporadically, due to genetic mutations, or by exposure to an already misfolded protein, leading to an abnormal three-dimensional structure that can propagate misfolding in other proteins.

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AA amyloidosis Abiogenesis Adnaviria Aeropyrum pernix Alpha-synuclein Alpha helix Alphasatellitidae Alternative splicing Alzheimer's disease Amino acid Amino acid sequence Ampullaviridae Amyloid Amyloid beta Amyloid plaques Amyloidosis Amyloids Amyotrophic lateral sclerosis Animal Anti-oxidative Antibody Antigen Apicoplast Archaea Archaeal transcription Archaeal translation Artificial cell Asparagine Astrogliosis Ataxia Autoclave Autophagy Avsunviroidae Aβ Bacillus licheniformis Bacillus subtilis Bacteria Bacterial transcription Bacterial translation Bacteriome Bartogtaviriformidae Basaltiviridae Beta sheet Bicaudaviridae Binding selectivity Bio-like structure Biological dark matter Bond cleavage Bone marrow Bovine spongiform encephalopathy Brachygtaviriformidae Brain CPEB Camel Camel spongiform encephalopathy Cancer cell Cat Cattle Cell-cell adhesion Cell (biology)Cell division Cell membrane Cellular death Central dogma of molecular biology Central nervous system Cerebral amyloid angiopathy Chaperone (protein)Chemical bond Chloroplast Chromoplast Chromosome Chronic wasting disease Circular chromosome Cis-regulatory element Clavaviridae Clonally transmissible cancer Coacervate Colicin Convulsion Cooperativity Copper Cosmid Creutzfeldt–Jakob disease Crohn's disease Cross-species transmission Cryo-electron microscopy Crystalline form DNA DNA replication DNA transposon DNA virus Dalton (unit)Daniel Carleton Gajdusek Daniel Mazia David Baltimore Defective interfering particle Dementia Denaturation (biochemistry)Detergent Dictionary.com Digestion Dinodnavirus Diseases of abnormal polymerization Disulfide bond Diversity-generating retroelement Domestic sheep Double-stranded RNA viruses DsDNA-RT virus Duplodnaviria Dura mater E.J. Field Earliest known life forms Efunaviria Elk Endogenous retrovirus Endogenous viral element Endosome Endosymbiont Enzyme Epigenetics Episome Equivalent concentration Eukaryote Eukaryotic transcription Eukaryotic translation Eurekaviridae Exocytosis Exotic ungulate encephalopathy Exponential growth Extrachromosomal DNA Familial Alzheimer-like prion disease Familial spongiform encephalopathy Fatal insomnia Feline spongiform encephalopathy Ferroptosis Fertility factor (bacteria)Fibril Five-prime cap Floreoviria Food Safety News Formaldehyde Fosmid Francevillian biota Francis Crick François Jacob Frontotemporal lobar degeneration Fungal prion Fungus Fuselloviridae Gary Taubes Gene Gene duplication Gene expression Gene regulatory network Genetic code Genome Genomic imprinting Genomic island Genotype Gerontoplast Gerstmann–Sträussler–Scheinker syndrome Giant virus Globuloviridae Glycolipid Glycophosphatidylinositol Goat Greater kudu Group II intron Group I catalytic intron Growth hormone Guanidinium chloride Guttaviridae HIV HIV/AIDS Halspiviridae HeLa Helper dependent virus Helper virus Hematopoietic stem cell Heterokaryon High affinity Hippocampus Histone acetylation and deacetylation Homograph Horizontal gene transfer Howard Martin Temin Hsp104 Huangdiviridae Human menopausal gonadotropin Huntington's disease Huntington's disease-like syndrome Hydrogenosome Hydrolysis Hypothesis ICD-10 ICD-11 Iatrogenesis Iatrogenic Idiopathic Immune response In vitro In vivo Incertae sedis Incubation period Infectious diseases (medical specialty)Infertility Inflammation Innate immunity Integrative and conjugative element International Statistical Classification of Diseases and Related Health Problems Interspersed repeat Intracellular signaling Intrinsically disordered protein Introduction to genetics Ion Ionizing radiation Isoform Itzamnaviridae Jacques Monod Jeewanu John Stanley Griffith Kappa organism Keratinase Knockout mouse Kuru (disease)LUCA Laboratory centrifuge Lac operon Last universal common ancestor Leucoplast Life Linear chromosome Linear function List of ICD-9 codes Lomiviridae Long-term memory Long-term potentiation Lysosome Mad cow crisis Major prion protein Mammal Manfred Eigen Median lethal dose Medical Subject Headings Medical specialty Messenger RNA Methionine MicroRNA Microbial dark matter Microparticle Mink Mitochondrion Mitosome Mobile genetic elements Mobilome Model lipid bilayer Moose Mule deer Multiple system atrophy Mycoplasma laboratorium Myelin Naldaviricetes Nanobacterium Nanobe Nattokinase Neurodegeneration Neurodegenerative disease Neurofibrillary tangles Neuron Nipumfusiviridae Nitroplast Nobel Prize Nobel Prize in Physiology or Medicine Nocardiopsis Non-cellular life Non-coding DNA Nucleic acid Nyala Obelisk (biology)Obscuriviridae Organelle Organism Origin of replication Oryx Ostrich Ovaliviridae Oxidation Oxidation state Ozone P-bodies PRNP Palliative care Parakaryon Parkinson's disease Pathogen Pathology Phagemid Phospholipase C Phosphorylation Plant Plasmaviridae Plasmid Plastid Platelets Pleomoviria Podospora anserina Polyadenylation Polyanions Polydnaviriformidae Portogloboviridae Pospiviroidae Post-transcriptional modification Post-transcriptional regulation Post-translational modification Post-translational regulation PrP systemic amyloidosis Preon Primary transcript Prion (bird)Prion disease Prion pseudoknot Prokaryote Promoter (genetics)Prophage Protease Proteasome Protein Protein dimer Protein folding Protein function Protein isoform Protein misfolding cyclic amplification Protein structure Protein tertiary structure Protein topology Proteinase K Proteinoid Proteinopathy Protein–protein interaction Proteolysis Protist Protocell Provirus R-factor RNA RNA-dependent RNA polymerase RNA polymerase RNA splicing RNA virus RNA world Reed Wickner Regulation of gene expression Repeated sequence (DNA)Replicon (genetics)Retron Retroposon Retrotransposon Retroviroid Retrovirus Retrozyme Reverse transcriptase-related cellular gene Reverse transcription Rheumatoid arthritis Rhizidiovirus Rhodogtaviriformidae Ribosome Ribosome-nascent chain complex Riboviria Ribozyme Ribozyviria Saccharomyces cerevisiae Satellite (biology)Schwann cells Scrapie Secondary chromosome Self-replication Serine protease Singelaviria Sodium hydroxide Sodium hypochlorite Spiegelman's Monster Spiraviridae Square root Stanley B. Prusiner Subtilisin Subviral agents Sulfoxide Sulphobes Sup35p Susan Lindquist Synthetic virology Synucleinopathy TARDBP Tandem repeat Tau protein Telomerase reverse transcriptase Text did not say about this even as of 2012 Thaspiviridae The University of Texas Health Science Center at Houston Thiourea Ti plasmid Tikvah Alper Tissue (biology)Tolecusatellitidae Transcription (biology)Transcription factor Transcriptional regulation Transfer RNA Transgenic mice Translation (biology)Translational regulation Transmembrane Transmissible mink encephalopathy Transmissible spongiform encephalopathy Transposable element Transpoviron Trophosome Tuberculosis University of California University of California, San Francisco Ure2 Urea Vacuole Variably protease-sensitive prionopathy Variant Creutzfeldt–Jakob disease Varidnaviria Vendobionta Viral vector Viriform Viroid Virome Virophage Virulence factor Virus Virusoid Volvereviria White-tailed deer Whitehead Institute World Health Organization Xenobot Xigoviridae Yamazakiviridae Yeast prion

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