Chaperone (protein)

Definition

In molecular biology, molecular chaperones are proteins that assist the conformational folding or unfolding of proteins or macromolecular protein complexes. There are a number of classes of molecular chaperones, all of which function to assist large proteins in proper protein folding during or after synthesis, and after partial denaturation. Chaperones are also involved in the translocation of proteins for proteolysis.

Related concepts

APPBP1 ATG12 ATG3 ATG7 ATG8 Adenosine diphosphate Adenosine triphosphate Aha1 Alpha crystallin Anfinsen's dogma Apoptosis Ataxin 3 BIRC6 Bacterial Bacterial adhesin Binding immunoglobulin protein Biological membrane CBL (gene)CDC34 CYLD (gene)Calnexin Calreticulin Capsid Catalysis Cdc37 Chaperome Chaperonin Chemical chaperones Clusterin Co-chaperone Cullin Cytosol DNA DNAJA1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB2 DNAJB4 DNAJB6 DNAJB9 DNAJC1 DNAJC10 DNAJC11 DNAJC13 DNAJC14 DNAJC19 DNAJC3 DNAJC5 DNAJC6 DNAJC7 Denaturation (biochemistry)Deubiquitinating enzyme DnaJ DnaK ERp29 ERp57 Endoplasmic reticulum Escherichia coli Escherichia virus T4 Eukaryote Eukaryotes FANCL FAT10 FUB1 Foldase GRP170 GRP94 Gene Gene expression Green fluorescent protein GroEL GroES GrpE HSF1 HSP100 HSP47 HSP60 HSP90AA2 HSP90AB1 HSP90B1 HSPA12A HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA4L HSPA6 HSPA7 HSPA8 HSPA9 Heat shock protein Heat shock protein 47 Heat shock protein 90kDa alpha (cytosolic), member A1 Histone Holdase Hsp104 Hsp27 Hsp33 Hsp40 Hsp70 Hsp90 Hydrophobic ISG15 Immunophilin In vitro In vivo Kilodalton Macromolecular crowding Matrix (biology)Mdm2 Membrane-anchored UBL Metallochaperones Mitochondria Molecular biology Molecular chaperone therapy Molecular machine Morphogenesis Multisystem proteinopathy Mutant NEDD8 Nanometer Neddylation Nucleoplasmin Nucleosome PIAS1 PIAS2 PIAS3 PIAS4 Pharmacoperones Polypeptide chain Post-translational modification Prions Prokaryotic ubiquitin-like protein Prolyl isomerase Protease Proteasome Protein Protein aggregation Protein degradation Protein dimer Protein disulfide isomerase Protein domain Protein dynamics Protein folding Protein precursor Protein synthesis Protein targeting Protein trimer Proteolysis Quaternary structure R. John Ellis Ron Laskey SAE1 SAE2 (yeast)SMN1 SMN2 STIP1 SUMO protein Saccharomyces cerevisiae Serine protease Signal peptide Steric Survival of motor neuron TRAP1 Target peptide Translation (biology)Translocon Type II secretion system UBA2 UBC9 UBE1 UBE1C UBE1DC1 UBE1L UBE1L2 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2I UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L2 UBE2L3 UBE2L4 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2R2 UBE2S UBE2V1 UBE2V2 UBE2Z UBL5 UBR1 UFC1 (gene)UFM1 URM1 USP6 Ubiquitin Ubiquitin-activating enzyme Ubiquitin-conjugating enzyme Ubiquitin-like protein Ubiquitin-proteasome system Ubiquitin conjugating enzyme E2 Q2 Ubiquitin ligase Von Hippel–Lindau tumor suppressor Yeast prions

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