Protein folding

Definition

Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random coil into a more ordered three-dimensional structure. This structure permits the protein to become biologically functional or active.

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APPBP1 ASIC ATG12 ATG3 ATG7 ATG8 Ab initio Alan Fersht Albumin AlphaFold Alpha crystallin Alpha helix Alpha solenoid Alzheimer's disease Amino acid Amphiphilic Amyloid Amyotrophic lateral sclerosis Anfinsen's dogma Antibodies Antitrypsin Anton (computer)Artificial intelligence Ataxin 3 BIRC6 Backbone chain Bacteria Bacteriophage T4 Bengt Nölting Beta-propeller Beta barrel Beta helix Beta pleated sheet Beta sheet Beta sheets Biliprotein Binding immunoglobulin protein Biomolecular structure Bovine spongiform encephalopathy Bruce Alberts Burn C-terminus CASP CBL (gene)CDC34 CYLD (gene)Catalysis Chaperone (protein)Chaperonin Chemical kinetics Chevron plot Chris Dobson Chromoprotein Circuit topology Circular dichroism Circular polarization Clusterin Coarse-grained modeling Computational biology Configuration space (physics)Conformational entropy Conotoxin Contact order Cooking Covalent bond Creutzfeldt–Jakob disease Cullin Cysteine Cystic fibrosis D. E. Shaw Research DNA DNAJA1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB2 DNAJB4 DNAJB6 DNAJB9 DNAJC1 DNAJC10 DNAJC11 DNAJC13 DNAJC14 DNAJC19 DNAJC3 DNAJC5 DNAJC6 DNAJC7 DNA clamp De novo gene birth Death fold DeepMind Denaturation (biochemistry)Denaturation midpoint Deubiquitinating enzyme Disease Disulfide bond Disulfide isomerase Downhill folding Dual-polarization interferometry Dual polarisation interferometry E. coli Edestin Egg white Emphysema Energy landscape Enthalpy Entropy Enzyme Equilibrium unfolding European Medicines Agency FANCL FAT10 FT-IR FUB1 Familial amyloid cardiomyopathy Familial amyloid polyneuropathy Fast parallel proteolysis (FASTpp)Ferredoxin fold Fibril Fibrils Flavodoxin fold Fluorescence spectroscopy Folding@home Folding (chemistry)Folding funnel Foldit Fourier transform Gibbs free energy Global distance test Globin fold Globular protein Globulin GroEL GroES HSP60 HSP90AA2 HSP90AB1 HSP90B1 HSPA12A HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA4L HSPA6 HSPA7 HSPA8 HSPA9 Harry Gray (chemist)Heat shock protein Heat shock protein 47 Heat shock protein 90kDa alpha (cytosolic), member A1 Helix bundle Heteronuclear single quantum coherence spectroscopy Homeodomain fold Hsp27 Hsp40 Hsp70 Hsp90 Huntington's Hydrogen bond Hydrophobic collapse Hydrophobic effect Hyperthermophiles ISG15 Immune system Immunoglobulin domain In silico In vitro In vivo Inclusion bodies Insoluble Intramolecular force Intrinsically disordered proteins Intrinsically unstructured proteins José Onuchic KaiB Lattice protein Leucine-rich repeat Levinthal's paradox Linus Pauling Lipid bilayer Lipocalin List of proteins London dispersion force Lubert Stryer Lysosomal storage diseases Macromolecule Magnetization transfer Markov state model Martin Gruebele Mdm2 Membrane-anchored UBL Membrane protein Molecular dynamics Multiple isomorphous replacement N-terminus NEDD8 Nanosecond Native state Neddylation Neurodegenerative Neurodegenerative disorder Nuclear Overhauser effect Nuclear magnetic resonance Nucleic acid Nucleic acid design Nucleic acid double helix Nucleic acid quaternary structure Nucleic acid secondary structure Nucleic acid sequence Nucleic acid structure Nucleic acid structure determination Nucleic acid structure prediction Nucleic acid tertiary structure Nucleic acid thermodynamics Optical tweezers PH PIAS1 PIAS2 PIAS3 PIAS4 Parkinson's disease Peptide bond Peptidyl-prolyl isomerase Peter Wolynes Pharmaceutical chaperones Phase problem Phi value analysis Photoreceptor protein Phycobiliprotein Physical process Phytochrome Picosecond Post-translational modification Potential energy of protein Precipitation (chemistry)Primary structure Prion Prokaryotic ubiquitin-like protein Proline Proteasome Protein Protein Data Bank Protein NMR Protein allergy Protein biosynthesis Protein conformation Protein design Protein domain Protein dynamics Protein engineering Protein folding problem Protein methods Protein misfolding cyclic amplification Protein primary structure Protein quaternary structure Protein secondary structure Protein structure Protein structure prediction Protein structure prediction software Protein targeting Protein tertiary structure Protein thermodynamics Proteinopathy Proteolysis Proteome Proteopathy Quantum chemistry Quantum yield RNA Ramachandran plot Random coil Reaction intermediate Relaxation (NMR)Ribonuclease A Ribosome Rosetta@home Rossmann fold SAE1 SAE2 (yeast)SH2 domain SH3 domain SMN1 SMN2 SOD1 SUMO protein Salt (chemistry)Science (magazine)Scleroprotein Self-assembly Sheena Radford Signal peptide Solutes Solvent Spin echo Spontaneous process Stopped flow Structural motif Survival of motor neuron TIM barrel TRAP1 Tafamidis Target peptide Temperature Temperature jump Thermodynamic free energy Thermostability Thioredoxin fold Time-resolved mass spectrometry Transition state Translation (genetics)Trefoil knot fold Tweet (social media)Twitter Two-dimensional nuclear magnetic resonance spectroscopy UBA2 UBC9 UBE1 UBE1C UBE1DC1 UBE1L UBE1L2 UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2I UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L2 UBE2L3 UBE2L4 UBE2L6 UBE2M UBE2N UBE2O UBE2Q1 UBE2R2 UBE2S UBE2V1 UBE2V2 UBE2Z UBL5 UBR1 UFC1 (gene)UFM1 URM1 USP6 Ubiquitin Ubiquitin-activating enzyme Ubiquitin-conjugating enzyme Ubiquitin-like protein Ubiquitin conjugating enzyme E2 Q2 Ubiquitin ligase Umbrella sampling Van der Waals forces Vibrational circular dichroism Virus Von Hippel–Lindau tumor suppressor Von Willebrand factor Water X-ray crystallography X-ray diffraction

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