Post-transcriptional modification

Definition

Transcriptional modification or co-transcriptional modification is a set of biological processes common to most eukaryotic cells by which an RNA primary transcript is chemically altered following transcription from a gene to produce a mature, functional RNA molecule that can then leave the nucleus and perform any of a variety of different functions in the cell. There are many types of post-transcriptional modifications achieved through a diverse class of molecular mechanisms.

Related concepts

3'UTR 3' UTR 5'UTR 5' UTR 5' cap 5'cap 7-methylguanosine Adenine Adenosine triphosphate Allele Alternative splicing Amino acid Antibody Archaeal transcription Archaeal translation Bacterial transcription Bacterial translation CCR4-Not CPSF-73 Cell nucleus Central dogma of molecular biology Chromosome Cis-regulatory element Classical genetics Cleavage and polyadenylation specificity factor Cleavage factor Cleavage stimulation factor Conservation genetics Core histones Cytogenetics Cytosol DCP1A DCP1B DCP2 DCPS (gene)DNA DNA sequencing Diphosphate EDC3 EDC4 Ecological genetics Enhancer (genetics)Epigenetics Eukaryote Eukaryotic Eukaryotic transcription Eukaryotic translation Evolution Exon Five-prime cap François Jacob Gene Gene expression Gene regulatory network Genetic code Genetic engineering Genetic variation Geneticist Genetics Genome Genomic imprinting Genomics Guanine Guanosine triphosphate Guanosyl transferase H2AFZ Heredity Histone Histone 3' UTR stem-loop Histone acetylation and deacetylation History of genetics Immunogenetics Index of genetics articles Introduction to genetics Intron Jacques Monod Lac operon Leeds Lubert Stryer MRNA MRNA (guanine-N7-)-methyltransferase Medical Subject Headings Medical genetics Mendelian inheritance Messenger RNA Messenger RNA decapping MicroRNA Microbial genetics Minor spliceosome Molecular evolution Molecular genetics Mutation New York City Nucleosome Nucleotide Open reading frame Operator (biology)Operator (genetics)Operon Outline of genetics P-bodies PABPN1 PLRG1 PRPF18 PRPF19 PRPF3 PRPF31 PRPF38A PRPF38B PRPF39 PRPF4 PRPF40A PRPF40B PRPF4B PRPF6 PRPF8 Personalized medicine Phosphodiester bond Phosphorylation Poly(A)-binding protein Poly(A) tail Poly-A tail Polyadenylate Polymerase Polyadenylation Polynucleotide adenylyltransferase Polyuridylation Population genetics Post-transcriptional regulation Post-translational modification Post-translational regulation Precursor mRNA Primary structure Primary transcript Prion Prokaryotic Promoter (genetics)Protein Protein coding region Proteins Proteolysis Quantitative genetics RNA RNA-Seq RNA-dependent RNA polymerase RNA Polymerase II RNA editing RNA polymerase RNA splicing RNA triphosphatase Regulation of gene expression Regulatory sequence Reverse transcription Ribonuclease Ribose Ribosomal RNA Ribosome Ribosome-nascent chain complex Ribosome binding site S-adenosyl methionine SLBP Silencer (genetics)Small nuclear RNA SnRNP Splice site Spliceosome Start codon Stop codon Terminator (genetics)Transcription (biology)Transcription (genetics)Transcription factor Transcriptional regulation Transfer RNA Translation (biology)Translation (genetics)Translational regulation U1 spliceosomal RNA U7 small nuclear RNA Untranslated region

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