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Transcriptional regulation

Definition

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response. Some examples of this include producing the mRNA that encode enzymes to adapt to a change in a food source, producing the gene products involved in cell cycle specific activities, and producing the gene products responsible for cellular differentiation in multicellular eukaryotes, as studied in evolutionary developmental biology.

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5-methylcytosineAcetylationActivator (genetics)Alternative splicingArchaeal transcriptionArchaeal translationBRCA1BRD4Bacterial transcriptionBacterial translationCDK8CDK9CTCFCancer epigeneticsCell nucleusCentral dogma of molecular biologyCis-regulatory elementCoactivator (genetics)Consensus sequenceCorepressor (genetics)CpG siteCpG sitesCytosineCytosolDNADNA demethylationDNA methylationDNA methyltransferaseEGR1Enhancer (genetics)EpigeneticsEukaryotesEukaryotic transcriptionEukaryotic translationEvolutionary developmental biologyFive-prime capFrançois JacobG bandingGeneGene expressionGene regulationGene regulatory networkGene silencingGeneral transcription factorsGenetic codeGenetic hitchhikingGeneticsGenomic imprintingGiemsa stainGuanineHSF1HistoneHistone acetylation and deacetylationHistone acetyltransferasesHistone deacetylaseHistone methyltransferaseHistonesHsp70HumanHuman genomeInsulator (genetics)Introduction to geneticsIntronsJacques MonodJohn StamatoyannopoulosKaryotypeLac operonMBD1MaltoseMeCP2Mediator (coactivator)Messenger RNAMethylMethyl-CpG-binding domainMethyl-CpG-binding domain protein 2MethylationMicroRNAMolecular biologyNon-coding DNANucleic acidNucleosomeOperonP-TEFbP-bodiesPOLR2APRC2PhosphorylationPolyadenylationPost-transcriptional modificationPost-transcriptional regulationPost-translational modificationPost-translational regulationPosttranslational modificationPrimary transcriptPrionPromoter (genetics)ProteinProtein isoformProteolysisRNARNA-dependent RNA polymeraseRNA Polymerase IIRNA polymeraseRNA polymerase IRNA polymerase IIRNA polymerase IIIRNA splicingRegulation of gene expressionRegulation of transcription in cancerRepressor (genetics)Reverse transcriptionRibosomal RNARibosomeRibosome-nascent chain complexSUMOylationSigma factorSignal transductionSilencer (genetics)Somatic evolution in cancerSuper-enhancerTET enzymesTopological association domainTranscription-translation couplingTranscription (biology)Transcription (genetics)Transcription factorTranscription factor II ATranscription factor II BTranscription factor II DTranscription factor II HTranscription factorsTranscription preinitiation complexTransfer RNATranslation (biology)Translational regulationUbiquitinYY1

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