Definition
Group I introns are large self-splicing ribozymes. They catalyze their own excision from mRNA, tRNA and rRNA precursors in a wide range of organisms. The core secondary structure consists of nine paired regions (P1-P9). These fold to essentially two domains – the P4-P6 domain and the P3-P9 domain. The secondary structure mark-up for this family represents only this conserved core. Certain subclasses of Group I introns also contain peripheral structural domains that provide additional structural support to the intron. Group I introns often have long open reading frames inserted in loop regions.
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