Epitranscriptome

Definition

Within the field of molecular biology, the epitranscriptome includes all the biochemical modifications of the RNA within a cell. In analogy to epigenetics that describes "functionally relevant changes to the genome that do not involve a change in the nucleotide sequence", epitranscriptomics involves all functionally relevant changes to the transcriptome that do not involve a change in the ribonucleotide sequence. Thus, the epitranscriptome can be defined as the ensemble of such functionally relevant changes.

Related concepts

2'-O-methylation 5-Methylcytosine 5′ cap ADAR ALYREF Acetylation Active site Adenosine Adenoviridae Adipose tissue Alternative splicing Antiviral therapy BRCA2 Base stacking Biotinylation Breast cancer CDKN2A Caenorhabditis elegans Cancer Cancer therapy Cell (biology)Central nervous system Chemical bond Circular RNA Codon Cofactor (biochemistry)Complementary DNA Computation Coronavirus Cytidine Cytoplasm DNA methylation DNA methyltransferase DNA repair DNA sequencing Database Denaturation (biochemistry)Dengue virus EF-Tu Elongator complex protein 5 Enhancer RNA Enzyme Epigenetics Epigenome Epitranscriptomic sequencing Eukaryote Eukaryotic initiation factor 3 Eukaryotic small ribosomal subunit (40S)Exon Exon skipping FTO gene Five-prime cap Flavivirus Gene expression Genome Guanosine Guanosine triphosphate HIV HNRNPC Half-life Heat shock Hepatitis C virus Herpes simplex virus Heterogeneous nuclear RNA Host (biology)Hydrolysis IFIT proteins Immune system Innate immune system Interferon Interferon type I Intron Isoform Knockout mouse Lean body mass Liquid chromatography–mass spectrometry Lone pair METTL14 METTL3 Mechanism of action Messenger RNA Methyl group Methylation Methyltransferase MicroRNA Mitochondrion Molecular biology N1-Methylguanosine N6-Methyladenosine Next-generation sequencing Nitrogen Non-coding RNA Nucleic acid sequence Nucleoside Oncogene Orthomyxoviridae P-bodies PUS1 Pancreatic cancer Peptidyl transferase Pluripotency Polyadenylation Polysome Polyuridylation Poxviridae Pre-mRNA Pre-mRNA processing Proinflammatory cytokine Protein family Pseudouridine Pus4 Pus7 protein Queuine RBM15 RNA RNA editing RNA modification Reverse transcriptase Ribonucleotide Ribosomal RNA Ribosome S-adenosylhomocysteine Secondary structure Single-nucleotide polymorphism Small nuclear RNA Small nucleolar RNA Stem-loop Stop codon Streptavidin Susan Baker (virologist)TRM4 (gene)TRNAMet cytidine acetyltransferase Three prime untranslated region Toll-like receptor Trans-splicing Transcriptome Transcriptomics Transfer RNA Translation (biology)Tumor progression Tumor suppressor gene Uridine Viral epitranscriptome Virus WTAP (gene)Watson-Crick base pair X-inactivation XIST YTHDC1 YTHDF3 YTH domain Yellow fever

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