Antisense RNA

Definition

Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein. The asRNAs have been found in both prokaryotes and eukaryotes, and can be classified into short and long non-coding RNAs (ncRNAs). The primary function of asRNA is regulating gene expression. asRNAs may also be produced synthetically and have found widespread use as research tools for gene knockdown. They may also have therapeutic applications.

Related concepts

5' end Activator (genetics)Alpha-thalassemia Antisense therapy Apolipoprotein B Arabidopsis thaliana Bacteria Bacterial artificial chromosome Bacteriophage CDKN2A CDKN2B CDKN2BAS CRISPR Cell nucleus Chaperone protein Chloroplast DNA Chromatin Cis-acting Cis-natural antisense transcript Cloning vector Complementary DNA Cosmid Cytomegalovirus retinitis Cytoplasm DNA DNA methylation Deoxyribonucleotide Deoxyribozyme Drug development Enhancer RNA Entamoeba histolytica Epigenetic Epigenetic regulation Escherichia coli Eukaryote Familial hypercholesterolemia Flowering Locus C Fomivirsen Fosmid Gene expression Gene knockdown Genomic DNA Glycol nucleic acid Guide RNA HOTAIR Hachimoji DNA Hemoglobin, alpha 1 Hexose Histone Histone methylation Histone modification Homeobox Human artificial chromosome IME4 Intergenic region Internal ribosome entry site Lambda phage List of RNAs Locked nucleic acid Locus (genetics)Long non-coding RNA Low-density lipoprotein cholesterol Messenger RNA MicF RNA MicroRNA Mipomersen Mitochondrial DNA Morpholino Multicopy single-stranded DNA Natural antisense transcript Non-coding RNA Nucleic acid Nucleic acid analogue Nucleobase Nucleoside Nucleoside-modified messenger RNA Nucleotide Oligonucleotide Oligonucleotide microarray Organellar DNA P1-derived artificial chromosome PRC2 Paul Zamecnik Peptide nucleic acid Phagemid Phosphorothioate nucleic acid Piwi-interacting RNA Plasmid Porin (protein)Post-transcriptional regulation Primary transcript Prokaryote Protein RME2 RNA RNA interference RNA virus RNAse H RNase MRP RNase P RasiRNA Retrotransposon Retrovirus Rho independent termination Ribonuclease Ribosomal RNA Riboswitch Ribozyme SECIS element Short hairpin RNA Signal recognition particle RNA Silencer (genetics)Small Cajal body-specific RNA Small hairpin RNA Small interfering RNA Small nuclear RNA Small nucleolar RNA Small temporal RNA Subgenomic mRNA Telomerase RNA component Threose nucleic acid Trans-acting Trans-acting siRNA Transcriptome Transfer-messenger RNA Transfer RNA Translation (biology)Vault RNA Very low-density lipoprotein Viroid XIST Xeno nucleic acid Y RNA Yeast artificial chromosome ZEB2 Zinc-finger

35 concepts already in your glossary