blanketglossary

Hypercycle (chemistry)

Definition

In chemistry, a hypercycle is an abstract model of organization of self-replicating molecules connected in a cyclic, autocatalytic manner. It was introduced in an ordinary differential equation (ODE) form by the Nobel Prize in Chemistry winner Manfred Eigen in 1967 and subsequently further extended in collaboration with Peter Schuster. It was proposed as a solution to the error threshold problem encountered during modelling of replicative molecules that hypothetically existed on the primordial Earth. As such, it explained how life on Earth could have begun using only relatively short genetic sequences, which in theory were too short to store all essential information. The hypercycle is a special case of the replicator equation. The most important properties of hypercycles are autocatalytic growth competition between cycles, once-for-ever selective behaviour, utilization of small selective advantage, rapid evolvability, increased information capacity, and selection against parasitic branches.

Related concepts

AbiogenesisAbundance (ecology)AcylationAcyltransferaseAminoacylaseAutocatalysisAutocatalytic setAutopoiesisAzoarcusBase pairCarsten BreschCatalysisCellular automatonCellular compartmentChannel capacityChemical equilibriumChemical kineticsChemical speciesChemistryChemotonChirality (chemistry)ConcentrationCooperationCooperative strategyCovalent bondDNA repairDNA replicationData storage deviceDifferential equationDirected evolutionDynamical systemEarthEnhancer (genetics)Environment (biophysical)EnzymeError catastropheError thresholdEvent (probability theory)EvolutionEvolutionary dynamicsEvolvabilityExponential growthEörs SzathmáryFitness (biology)Flux (metabolism)Francisco VarelaFreeman DysonGenetic codeGenetic diversityGenetic recombinationGenomeGinestra BianconiHumberto MaturanaHydrolysisIn situInformationInstabilityJacek BłażewiczJohn Maynard SmithKarl SigmundLast universal common ancestorLigaseLigation (molecular biology)List of Nobel laureates in ChemistryMacromoleculeManfred EigenMathematics of oscillationMembraneMichaelis–Menten kineticsMutationNAD+ synthaseNonlinear systemNucleic acidNucleic acid sequenceNucleobaseOligomerOpen accessOrdinary differential equationPLOS Computational BiologyParasitic RNAParasitismPartial differential equationPaulien HogewegPeptidePeptide bondPeptidyl transferasePeriodic sequencePeter Schuster (theoretical chemist)PolymerasePopulation (biology)Positive feedbackPrebiotic worldProteinPyrimidineQuadratic differentialQuasispeciesQuasispecies modelRNARNA-dependent RNA polymeraseRecombinaseReplicator equationRibozymeRobert May, Baron May of OxfordRobert Rosen (theoretical biologist)Selection (biology)Self-assemblySelf-informationSelf-organizationSelf-replicatingSense (molecular biology)Sequence motifSilencer (DNA)Spiral waveStochastic processStuart KauffmanSynthaseSystemTibor GántiTransfer RNATranslation (biology)Ultraviolet germicidal irradiation

36 concepts already in your glossary