Cas9

Definition

Cas9 is a DNA cutting enzyme that is part of the CRISPR immune system in bacteria and archaea. It has been adapted to be used as a CRISPR genome editing tool that enables targeted modification of DNA sequences and permanently changes a cell’s genome.

Related concepts

/Activator (genetics)Adaptation Adaptive immune system Aedes aegypti Alanine AlphaFold Amino acid Apoenzyme Archaea Bacterial genome Bacteriophage Binding site Biological half-life CRISPR CRISPR RNA CRISPR activation CRISPR gene editing CRISPR interference Caenorhabditis elegans Candida albicans Cas12a Cas3 Cas gene Catalytic Chimera (genetics)Chromatin Chromosome Cofactor (biochemistry)DCas9 activation system DNA DNA virus Emmanuelle Charpentier Endonuclease Endoribonuclease Entrez Enzyme Enzyme Commission number Eukaryote Feng Zhang Gene drive Gene expression Genetic engineering Genome Genome editing George Church (geneticist)Guide RNA Harpegnathos saltator Hepatitis B Heterochromatin Homologous recombination Human genetic enhancement Indel InterPro Jennifer Doudna Locus (genetics)Model organism Molar concentration Mus musculus domesticus National Center for Biotechnology Information Nobel Prize in Chemistry Non-homologous end joining Nucleic acid Off-target genome editing Ooceraea biroi PDBe-KB Plasmid Protein Data Bank Protein engineering Protospacer adjacent motif RNA RNA interference RNA polymerase RNAi Reaction rate constant Repressor Repressors Restriction enzymes Ribonucleoprotein Saccharomyces cerevisiae Stem-loop Stoichiometry Streptococcus pyogenes Swiss-Prot TracrRNA Transcription (genetics)Transcription activator-like effector nuclease Transcription factors Transcriptional activator Triparna Sen Turnover number UniProt Urea Valence (chemistry)Virginijus Šikšnys Virus Zebrafish Zinc finger nuclease Zinc fingers

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