Non-covalent interaction

Definition

In chemistry, a non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule. The chemical energy released in the formation of non-covalent interactions is typically on the order of 1–5 kcal/mol. Non-covalent interactions can be classified into different categories, such as electrostatic, π-effects, van der Waals forces, and hydrophobic effects.

Related concepts

Acetone Agostic interaction Alkali metal Amino acids Angle strain Anion Arene Aromatic Aromaticity Atom Aurophilicity Baird's rule Bent bond Bicycloaromaticity Binding constant Binding site Boiling point Bond cleavage Calorie Carbon tetrachloride Carbonyl Cation Cation–pi interaction Chalcogen bond Charge-shift bond Chemical bond Chemical energy Chemistry Chloroform Cofactor (biochemistry)Conjugate base Conjugated system Coordinate covalent bond Coulomb's law Covalent bond Crystallinity C–H···O interaction DNA Debye force Diethyl ether Dihydrogen bond Dipole Dipole-dipole interactions Dipole–dipole interaction Drug design Eight-center two-electron bond Electromagnetic interaction Electron Electron counting Electron deficiency Electronegative Electronegativity Electrophile Electrostatic interactions Electrostatics Enthalpy Enzyme Enzyme inhibitor Ethanol Fluorine Formal charge Four-center two-electron bond Gas Halogen Halogen bond Halogen bonding Hapticity Heterolysis (chemistry)Hexane Homoaromaticity Homolysis (chemistry)Hydrogen bond Hydrogen bonding Hydrogen bonds Hydrophobic collapse Hydrophobic effect Hyperconjugation Hypervalent molecule Hückel's rule Intercalation (chemistry)Intermolecular force Intermolecular forces Intramolecular force Ion Ionic bond Ionic bonding Jemmis mno rules Keesom force Linus Pauling Liquid London dispersion force London dispersion forces Low-barrier hydrogen bond Mechanically interlocked molecular architectures Metal aromaticity Metallic bonding Metallophilic interaction Metal–ligand multiple bond Mole (unit)Molecular chaperones Molecular dipole moment Molecular mass Molecule Möbius aromaticity N-butanol Nitrogen Non-covalent interactions Nucleic acid Nucleophile Organic molecule Organic synthesis Oxygen Pi-stacking Pi backbonding Pi interaction Polarizability Polyhedral skeletal electron pair theory Potential energy Protein Protein folding Protein quaternary structure Protein secondary structure Protein structure Protein tertiary structure Proteins Receptor (biochemistry)Resonance-assisted hydrogen bond Salt bridge Salt bridge (protein and supramolecular)Self-assembly Sodium ethoxide Sodium fluoride Solvation Solvent Spherical aromaticity Stacking (chemistry)Steric effects Sterics Strain (chemistry)Sublimation (chemistry)Sulfur Symmetric hydrogen bond Tetrachloromethane Three-center four-electron bond Three-center two-electron bond Transition metal Van der Waals force Van der Waals forces Van der Waals interactions Vapor pressure

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