Definition
Chemogenetics is the process by which macromolecules can be engineered to interact with previously unrecognized small molecules. Chemogenetics as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on substrate specificities in the flowers of Dianthus caryophyllus. This method is very similar to optogenetics; however, it uses chemically engineered molecules and ligands instead of light and light-sensitive channels known as opsins.
Related concepts
Brain circuitBryan RothCentral nervous systemChalcone isomeraseDeep brain stimulationDianthus caryophyllusG-protein coupled receptorsGamma-aminobutyric acidGene therapy for epilepsyGlutamic acidKinaseMacromoleculeMetabolismNeurodegenerationNeuropsychiatryNucleic acid hybridizationOpsinOptogeneticsOrbitofrontal cortexParkinson's diseaseReceptor activated solely by a synthetic ligandRhinal cortexTranscranial magnetic stimulationWild type
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