Definition
In genetic epidemiology, endophenotype is a term used to separate behavioral symptoms into more stable phenotypes with a clear genetic connection. The concept was coined by Bernard John and Kenneth R. Lewis in a 1966 paper attempting to explain the geographic distribution of grasshoppers. They claimed that the particular geographic distribution could not be explained by the obvious and external "exophenotype" of the grasshoppers, but instead must be explained by their microscopic and internal "endophenotype". The concept has gained popularity in research on anxiety and affective disorders.
Related concepts
5-HT1B receptorADHDAddictionAggressionAlzheimer's diseaseAmygdalaAnterior cingulate cortexBiological markersBiomarkerBipolar disorderCHRNA7Cav1.2Cystic fibrosisDiathesis–stress modelEEG microstatesEcophenotypic variationEdward T. BullmoreElectroencephalographyFABP7FMRIFace perceptionGenetic epidemiologyGeneticsGrasshopperImpulsivityObesityPhenotypesPopulation distributionPrefrontal cortexPrepulse inhibitionProbandsPsychiatric geneticsPsychosisReelinSchizophreniaSensory gatingSerotoninSingle nucleotide polymorphismStriatumSuicideSymptomVoltage-dependent calcium channelWorking memory
2 concepts already in your glossary